KEENE, NH — Keene State College has announced that the following Wilmington student has been named to the Fall 2018 Dean’s List:Deeanna MallettAbout Keene State CollegeKeene State College is a preeminent public liberal arts college that ensures student access to world-class academic programs. Integrating academics with real-world application and active community and civic engagement, Keene State College prepares graduates to meet society’s challenges by thinking critically, acting creatively, and serving the greater good. To learn more about Keene State College, visit http://www.keene.edu.(NOTE: The above announcement is from Keene State College via Merit.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Thank You To Our Sponsor:Share this:TwitterFacebookLike this:Like Loading… Related3 Wilmington Students Named To Dean’s List At Keene State CollegeIn “Education”STUDENT SPOTLIGHT: Wilmington’s Pumphret & Rae Named To Dean’s List At Keene StateIn “Education”Wilmington’s Mallett, Mazzie & Rae Named To Dean’s List At Keene StateIn “Education”
Solís’ U.S. travels continue in Washington, D.C., where he met with members of the Congressional Black Caucus, the House of Representatives’ Foreign Affairs Committee, and Senate Democrats and Republicans to discuss economic development, regional security, climate change and sustainable development on Thursday. He returns to Costa Rica on Friday. Costa Rica President Luis Guillermo Solís called for a more “proactive,” interventionist United Nations Security Council during his address before the U.N. General Assembly Wednesday morning. Solís had strong words for the Security Council for its perceived inaction in preventing and combating crimes against humanity and its lack of progress in disarming nuclear powers.“The council’s focus on conflict prevention is inadequate, and when it does take action, it often comes too late,” Solís told the audience of world leaders in New York, referencing conflicts in Syria, Yemen, Libya and the genocides in Rwanda and Srebrenica. “None of these crises emerged without prior warning.”Solís’ more interventionist view of the U.N. came into view when he addressed the obligations of member states, especially Security Council members: “When governments fail to meet the responsibility to protect, either because they lack the will or the ability to safeguard the rights of their own people, then it is up to the international community, and in particular the Security Council, to intervene and deploy the wide variety of resources at its disposal to resolve conflicts.”That ability to intervene, however, has been quashed by the threat of a veto by the Security Council’s permanent members, Solís said. According to the U.N. Charter, if any of the five permanent members of the Security Council — the U.S., U.K., France, Russia and China — cast a veto in the 15-member Security Council, the resolution or decision does not pass. The president called for a reform to the veto power of the Security Council, saying that the mechanism undermines the mission of the United Nations and member-states’ trust in the U.N.’s ability to resolve the difficult conflicts it was designed to tackle. Que se impida el uso del veto cuando se comentan genocidios, crímenes de guerra o crímenes de lesa humanidad #UNGA— Luis Guillermo Solís (@luisguillermosr) September 30, 2015 «Ha llegado la hora de que la ONU esté encabezada por una mujer»: presidente de Costa Rica http://t.co/j2SFALThAU pic.twitter.com/Wc3Eb7JI5I— Naciones Unidas (@ONU_es) September 30, 2015 En el Comité de Asuntos Exteriores de la Cámara de Representantes de Estados Unidos pic.twitter.com/yYeV3BRqlq— Luis Guillermo Solís (@luisguillermosr) October 1, 2015 Facebook Comments Nos reunimos con el Comité de Asuntos Exteriores de la Cámara de Representantes de EEUU pic.twitter.com/C9EyKx9cCK— Luis Guillermo Solís (@luisguillermosr) October 1, 2015 Read Solís’ full U.N. General Assembly address in Spanish and English below: Solís said Costa Rica supports a reform proposed by France, a permanent member of the Security Council, which would establish a Code of Conduct that would prohibit Security Council members from using their veto power in situations of genocide, war crimes and crimes against humanity, and “demand a political commitment to act promptly and decisively in such situations.”“The opinion of a single permanent member cannot continue to bear more weight than the necessity to save lives,” Solís said.Solís also called on nuclear powers to make good on their pledge to disarm under the Treaty on the Non-Proliferation of Nuclear Weapons. The president said that nuclear weapons were often on hair triggers and suggested that they were susceptible to cyber-attack.Gender equality was also on Solís’ mind as he reiterated Costa Rica’s support for serious consideration among member countries of women to lead the U.N.“The time has come for the General Secretariat to be occupied by a woman,” he said. Related posts:Costa Rica to ‘take a hard look’ at its diplomatic missions, foreign minister says after meeting with US Secretary of State Kerry Pope Francis calls for climate, migrant action in Congress speech President Solís to support reforms, female leadership at United Nations President Solís meets with Palestinian Authority President Mahmoud Abbas at UN
The Ukrainian Media Group has launched trial versions of film channel Kinotochka and drama channel NLO-TV.The company has struck a deal with national digital TV network Zeonbud for both channels. Kinotochka airs movies, series and documentary feature films, while NLO-TV airs mostly mystery dramas.However, the company will not be launching the news channel Novosti after it was refused a national licence. “We are not planning to develop the Novosti channel, as we did not receive the licence [for national digital broadcasting],” the group’s director-general Fedir Oharkov told local press.
UK broadcaster Channel 4 is taking a minority equity stake in the all-you-can-read digital magazine provider, Readly.The airtime-for-equity deal, struck between Readly and Channel 4’s Commercial Growth Fund, will see the broadcaster take the stake in exchange for airing Readly’s first TV advertising campaign across its linear channel network.“We are impressed by Readly’s strong value proposition to consumers and the company’s entrepreneurial ambition,” said the head of Channel 4’s Commercial Growth Fund, Vinay Solanki.“We believe their innovative business model will benefit from TV advertising exposure across our network enabling them to access our core young upmarket audience, to help this business grow their foothold in the UK digital subscription market,”Ranj Begley, managing director, Readly UK, said: “With Channel 4 as a partner, we have a mainstream TV presence and the opportunity to scale up our audience much more rapidly than we had originally forecast.”Channel 4’s Commercial Growth Fund launched last year and the scheme allows brands to “accelerate their growth through TV promotion”. The fund has already made partnerships with digital music service Deezer, tonic water company Fever-Tree and the recruitment app Jobandtalent.Readly gives users unlimited access more than 1,500 digital magazine titles for a £7.99 per month subscription fee.
Americans are falling behind on their car payments…If you’ve been reading the Dispatch, you know the price of oil has plummeted as much as 75% since June 2014. Two months ago, it hit its lowest level since 2003.Since then, oil has rebounded 45%. But even after that big bounce, oil is down 61% from its 2014 high.• The world has too much oil…New technologies like “fracking” have unlocked billions of barrels of shale oil that was once impossible to extract. From 2007 to 2014, oil production in U.S. shale regions jumped eight-fold.For a while, this led to a huge boom in shale oil stocks. Occidental Petroleum (OXY), the largest U.S. shale company, jumped 158% from 2007 to June 2014. EOG Resources (EOG), the second-largest, surged 300%.• But when oil prices crashed, oil stocks crashed, too…The Market Vectors Unconventional Oil & Gas ETF (FRAK) has plunged 58% since June 2014. This fund tracks U.S. shale oil and gas companies.Shares of the world’s five biggest oil companies—Exxon Mobil (XOM), Chevron (CVX), BP (BP), Total SA (TOT), and Royal Dutch Shell (RDSA.L)—have fallen an average of 29% over the same period.Schlumberger (SLB), the world’s largest oil services company, has plunged 36%. Oil services companies sell “picks and shovels” to the oil industry.• Oil and gas companies slashed spending by 23% last year…They sold pieces of their businesses. They abandoned more than $100 billion in projects. The industry has even laid off more than 250,000 workers since oil prices peaked.And more job cuts are likely coming. Investment bank Barclays expects oil and gas companies to cut spending by another 15% this year.• The oil crisis is spreading to the car industry…During the boom times, oil “roughnecks,” who work on the drilling rigs, were easily making more than $100,000 a year.Now thousands of these folks are out of work…or have taken huge pay cuts. Just like businesses, people have to cut expenses when they’re making less money. And people in major oil-producing states aren’t paying their car bills…CNNMoney reported last week:North Dakota, the epicenter of the shale oil boom and subsequent bust, experienced a 42% spike in seriously delinquent (60 days or more) auto loans during the fourth quarter, according to TransUnion.Louisiana, another state hit hard by the oil crash, had the highest auto delinquency rate, while late payments in Texas and Oklahoma jumped about 14% apiece.• Delinquency rates could keep rising…Many shale oil companies need $50 oil to make money. With oil at $41 a barrel, lots of companies are still losing money.Half of U.S. shale oil companies could go bankrupt, according to CNNMoney. Tens of thousands more oil workers could lose their jobs.• As Dispatch readers know, borrowed money caused the U.S auto industry to boom…Auto sales have climbed six consecutive years. Last year, U.S. auto sales hit an all-time record of 17.5 million.Americans bought many of these cars on credit. Since 2010, the total amount of U.S. auto loans has surged 50%. Last year, the auto loan market topped $1 trillion for the first time ever.A few weeks ago, we explained what’s driving this borrowing frenzy. In short, it’s never been cheaper or easier to get an auto loan. Borrowing costs have collapsed. In 2007, the average interest rate for an auto loan was 7.7%. Today, it’s 4.3%.• The auto loan industry is starting to crack… Subprime auto loan delinquencies hit a twenty-year high last month. “Subprime” describes a loan made to someone with bad credit.Financial Times reported last week:The rate of “subprime” motor loans overdue by more than 60 days rose to 5.16 per cent in February. This surpassed the post-financial crisis peak and was the highest since the 5.96 per cent reading in October 1996, according to the rating agency. — Mark Ford: Join me Tonight [free event]I hope you’ll join me for a special online training event tonight, Monday, March 21st… I’ll discuss income ideas that work in any economy. Whether you are young or old… retired or still working… in debt or well-off. I call them “Extra Income Opportunities.” And I want to send you your first “Opportunity” right now, if you sign up here… (It’s free!) Recommended Links What you need to know about the incredible opportunity in gold, right nowWe recently put together a presentation revealing the single best opportunity you have to make 500%+ gains in gold over the coming years. This is one of those extremely rare chances you almost never get to make outrageous returns with even a small investment. See more, here. – • Subprime auto loans are the new subprime mortgages…Reckless lending practices fueled the housing run-up from 2000 to 2005. Thinking housing prices would “never fall,” lenders issued mortgages to folks who couldn’t afford it. When housing prices crashed, subprime borrowers defaulted on their loans. The implosion of the housing industry sparked the 2008 financial crisis.• Investors who predicted the housing collapse made a fortune…Hedge fund managers like John Paulson and Kyle Bass knew housing prices would eventually fall back down to earth. They made billions betting against lenders who made bad loans.Companies like Washington Mutual, a savings bank holding company, suffered huge losses during the 2008 financial crisis. It eventually went out of business.• Several Dispatch readers have asked how to bet against the subprime auto loan market…From 2000 to 2005, DR Horton (DHI), the largest U.S. home builder, gained more than 1,100%. Lennar Corporation (LEN), the second-largest, gained nearly 900%.The crazy run-up in these stocks made them obvious short candidates. When the housing crisis hit, DR Horton’s stock plunged 89%. Lennar plunged 94%.Despite record car sales, U.S. carmakers haven’t had a big rally. In fact, they haven’t gone up at all. General Motors (GM), the largest U.S. carmaker, has fallen 14% since 2011. Ford (F) has dropped 21%.We don’t know why record car sales have failed to spark a rally in U.S. automaker stocks. Perhaps folks are wising up to the Fed’s funny money. After all, the housing crash wiped out millions of people financially. Investors who see that cheap credit is the only thing driving record auto sales are saying “we’re not falling for that again.”• We don’t recommend shorting automaker stocks…But there is a way to “short” the fragile auto loan market. You can bet against the reckless government policies that caused the lending craze in the first place.Regular readers know the Federal Reserve has pinned its key interest rate near zero since 2008. This has made it extremely cheap to borrow money not just for cars, but for everything. With interest rates at ridiculously low levels, nothing is too expensive or too extravagant for Americans to buy.All this cheap money has pushed prices of commercial property, stocks, and bonds to all-time highs.Meanwhile, the “real” U.S. economy has barely grown since 2009. The financial system has lost touch with reality. We’re now living in an “Alice in Wonderland” economy.• The market needs to unwind years of reckless borrowing…Industries that thrived on easy money will suffer huge losses. Stocks and assets that boomed on easy money will crash.When the financial system has its “reality check,” gold will be the big winner. Gold is a safe-haven asset. Investors turn to gold during times of uncertainty because gold is money. It’s preserved wealth for thousands of years through every kind of financial crisis and reckless government policy.Just last week, Casey Research founder Doug Casey said buying gold is “really a way to short government—or go long on government stupidity.”We suggest holding cash, too. As we mentioned, stocks, bonds, and commercial property prices are all near record highs. They will likely plunge during the next crisis. Setting aside cash will put you in a position to buy stocks when they get cheap.For our best advice on how to protect your wealth, we encourage you to read our newest book, titled Casey Research’s Guide to Surviving the Coming Financial Crisis. In it, we explain how to protect yourself from stock market crashes, economic recessions, and even destructive government policies. Click here to claim your copy.Chart of the DayLarge American car stocks have been dead money.Today’s chart shows the performance of General Motors (GM), Ford (F), and the S&P 500 since 2011. You can see that GM and Ford have done far worse than the S&P 500…despite six straight years of rising auto sales.Although cheap money has goosed auto sales, it has failed to boost auto stocks. You would have lost money investing in Ford and GM over the last five years.Regards,Justin SpittlerDelray Beach, FloridaMarch 21, 2016We want to hear from you.If you have a question or comment, please send it to email@example.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful.
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Disabled peers have demanded that the government rips up its “frustrating”, “clichéd” and “tepid” response to a major House of Lords report on the Equality Act’s impact on disabled people.The Equality Act 2010 and disability committee reported in March on how equality legislation affects disabled people, following a nine-month inquiry.The committee concluded that the government was failing to protect disabled people from discrimination, and that laws designed to address disability discrimination were “not working in practice”, while spending cuts were having “a hugely adverse effect on disabled people”.An analysis by Disability News Service of the government’s response to the report, which was published in July, suggested that it accepted in full only about eight of the committee’s 55 recommendations.In a Lords debate on the report this week, disabled peers lined up to criticise the government’s response.Baroness [Jane] Campbell (pictured, left, during the debate), who sat on the committee, said that its report recommends “workable, low-cost, legislative and practical changes that would greatly enhance equality for disabled people in this country”.But she described “disabled people’s frustration at the failure of the government to embrace the recommendations more fully”, and called on it to “go back to the drawing board”.She criticised the government’s use of “the exhausted cliché that regulation will not change hearts and minds” when “all the evidence shows that without legislation we cannot win ‘hearts and minds’”.And she said that Sir Bert Massie, the former chair of the Disability Rights Commission, had told her that the government’s “tepid” response to the report “clearly demonstrates a deep lack of understanding and concern about Britain’s disabled people”.Baroness [Sal] Brinton (pictured, right), president of the Liberal Democrats, who also sat on the committee, said the government had showed in responding to the report’s recommendations that it “will not even regulate, let alone legislate”.She said: “I join colleagues on the select committee in hoping that the previous government’s report back to us will be discarded.“I have high hopes, because the evidence in the select committee report is so strong and will not go away.“I call for the new government [under Theresa May, rather than David Cameron] to prove that they truly believe in inclusion by going back and rewriting their response.”Her fellow disabled Liberal Democrat peer, Baroness [Celia] Thomas, whose idea it was to hold the inquiry, called on the government to “implement our recommendations without delay. There is no excuse for not doing so”.The disabled crossbench peer Lord [Colin] Low, who did not sit on the committee, praised the “excellent” report.He said that the government’s “drive to reduce regulation and red tape has resulted in rules and provisions that were helpful to disabled people being weakened or abolished”.He said: “The report makes an important point when it says that these things should properly be seen as protections for disabled people rather than burdens on business, and that their removal under the [government’s] Red Tape Challenge should be reversed.”Another disabled peer, the Liberal Democrat Lord Addington, said there was a need for “aggressive action” to enforce equality.He said: “We here have to start pointing out to the rest of society that it will benefit by taking this appropriate action.“If we make people with disabilities more economically active and more socially included, we will save ourselves hassle and trouble.”The Conservative Home Office minister, Baroness Williams, said the report was “timely and comprehensive and highlights the continuing challenges and obstacles which disabled people face on a daily basis”.She said it “rightly focused on a number of important issues, such as how adequately we imbed disabled people’s needs into the first steps to plan services and also when we construct premises”.She added: “The report also fairly examined whether both public and private sectors have been sufficiently proactive in meeting the needs of citizens with a disability and whether there is still a tendency simply to react to problems once they have arisen or to be forced into action when pressed.“We further acknowledge the importance of two-way communication between government and disabled people and their representatives, something that the report says we can improve on, in turn improving access to justice and how services are delivered.”
The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apple Reportedly Budgets $1 Billion for Original Programming That’s about half of what HBO spent on content in 2016, and the same amount Amazon spent on programming in 2013, according to The Wall Street Journal. –shares This story originally appeared on PCMag Add to Queue Angela Moscaritolo Apple Apple’s first original TV shows are no Game of Thrones, but the Cupertino tech giant is ready to shell out some serious cash to produce a comparable hit.The Wall Street Journal, citing unnamed people familiar with the matter, on Wednesday reported that Apple is budgeting “roughly $1 billion” over the next year for its push into original content. That’s about half of what HBO spent on its shows in 2016, and the same amount Amazon spent on programming in 2013, the report notes.The Journal’s sources reckon that Apple could produce as many as 10 TV shows with that money. Apple Senior Vice President Eddy Cue wants the company’s shows to stack up against Game of Thrones, according to the report. Something of that caliber could cost more than $10 million per episode to produce.Apple’s first original show, Planet of the Apps, debuted in June to mediocre reviews. The show is basically Shark Tank for apps: every episode, entrepreneurs have 60 seconds to pitch their apps to four celebrity advisors. PCMag’s Chandra Steele, who watched the show so you don’t have to, said “40 minutes of discussions about products that are best viewed on a smartphone screen is not exactly must-see TV.”Meanwhile, early reviews of Apple’s second original show, Carpool Karaoke: The Series, which debuted last week, have also been lukewarm. Based on the popular segment from The Late Late Show with James Corden, the series features 16 celebrity pairings “riding along in a car together as they sing tunes from their personal playlists and surprise fans who don’t expect to see big stars belting out tunes one lane over,” Apple said. 2019 Entrepreneur 360 List 2 min read Image credit: Planet of the Apps August 17, 2017 Apply Now » Reporter Next Article
Small Business Heroes Tebowing.com: Scrambling to Build a Business on a Viral Trend Next Article Brad Crescenzo Add to Queue –shares Learn how to successfully navigate family business dynamics and build businesses that excel. 3 min read Opinions expressed by Entrepreneur contributors are their own. What could be harder than starting a viral Internet meme? How about building a successful business around one.But that’s just what Jared Kleinstein, creator of Tebowing.com, is seeking to do.He didn’t set out to. Inspiration hit to build his tribute website after watching the October Broncos-Dolphins football game in a bar with friends.Related Video: A Fashion Startup Goes ViralAt the start of the fourth quarter, a Broncos victory seemed hopeless. But miraculously, Denver scored two touchdowns in quick succession, then secured the win in overtime. While everyone else celebrated, Broncos quarterback Tim Tebow struck what’s become his signature pose, dropping to one knee, fist tucked under his chin, and prayed.Kleinstein and his friends walked out of the bar, and took a picture as they recreated Tebow’s famous move, which Kleinstein would coin “Tebowing.” Tebow, the son of Christian missionaries, has always been proud of his faith. Free Webinar | July 31: Secrets to Running a Successful Family Business The next day, Kleinstein launched Tebowing.com. He told a few friends about it and encouraged them to post their pictures. By the end of its first full day, the site received about 850 unique views. The next day, that figure had risen to about 10,000. The next day, 350,000. Kleinstein received a text message from a friend telling him to turn on CNN: Tebowing had officially gone viral, making national news in about three days. The site has since been attracting up to 15,000 page views per day since the initial rush, and received over 12,500 photo submissions.Related: Ten Hot Startup Business IdeasKleinstein had no intention of making Tebowing.com a business. “It’s kind of the opposite of the American business plan… This business was created after the product was already in place,” says the 24-year-old web professional who lives in Manhattan and has a degree in marketing and entrepreneurship.Kleinstein scrambled to build a business and capitalize on the site’s popularity. He used an open-source template to create a blog-style website. He then used a do-it-yourself apparel platform called Spreadshirt.com to produce and distribute his Tebowing merchandise, which includes T-shirts, hoodies, baby bibs, and dog bandannas which sell for $15 to $40. Jared declined to disclose revenues, but did say a portion goes to local Denver charities but he hasn’t quit his day job at StreetEasy.com. a real-estate listings company.The sustainability of businesses based on popular fads can be difficult to predict, says Ben Huh, CEO of the Cheeseburger Network, a Seattle Wash.-based company which runs five popular blogs, including icanhascheeseburger.com. His advice? Do what you love, connect with the site’s community, and concentrate on offering good content, not chasing fads. A website is a business, and it should be treated like a business, he says. “If your business plan relies on luck, good luck with that.”Related: Chief Cheezburger Ben Huh Dishes on Social Media December 1, 2011 Register Now »
Reviewed by James Ives, M.Psych. (Editor)Oct 23 2018The entrainment of theta brain waves with a commercially available device not only enhances theta wave activity, but also boosts memory performance. That’s according to new research from the Center for Neuroscience at the University of California, Davis, published recently in the journal Cognitive Neuroscience.Electrical activity in the brain causes different types of brain waves that can be measured on the outside of the head. Theta waves occur at about five to six cycles per second, often associated with a brain that is actively monitoring something — such as the brain of a rat navigating a maze.In an earlier study, Charan Ranganath, professor of psychology, and colleagues at the Center for Neuroscience found that high levels of theta wave activity immediately before a memory task predicted better performance.”Entrainment” devices use a combination of sound and lights to stimulate brain wave activity. The idea is that oscillating patterns in sensory inputs will be reflected in brain activity. The devices are marketed to address a range of problems such as anxiety, sleep issues, “low mood” and learning. However, there is very little published scientific evidence to support these claims.Related StoriesRush University Medical Center offers new FDA-approved treatment for brain aneurysmsDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustPosterior parietal cortex plays crucial role in making decisions, research showsBrooke Roberts, a postdoctoral researcher in Ranganath’s lab, obtained a theta wave entrainment device and decided to test it. She had 50 volunteers either use the device for 36 minutes, or listen to 36 minutes of white noise, then do a simple memory test.Improved memory performanceThe subjects who had used the device showed both improved memory performance and enhanced theta wave activity, she found.Roberts showed her results to Ranganath, who was intrigued but cautious and suggested new controls. They repeated the experiment with another 40 volunteers, but this time the control group received beta wave stimulations. Beta waves are a different type of brain wave pattern, occurring at about 12 to 30 cycles per second, associated with normal waking consciousness.Once again, theta wave entrainment enhanced theta wave activity and memory performance.Ranganath’s lab also conducted a separate study using electrical stimulation to enhance theta waves. However, this actually had the opposite effect, disrupting theta wave activity, and temporarily weakened memory function.Ranganath said he’s surprised the devices work as well as they appear to do.”What’s surprising is that the device had a lasting effect on theta activity and memory performance for over half an hour after it was switched off,” he said.There is debate among neuroscientists over the function and role of these brain waves. Some researchers argue that they are simply a product of normal brain function with no particular role. Ranganath, however, thinks that they may play a role in coordinating brain regions.”The neurons are more excitable at the peak of the wave, so when the waves of two brain regions are in sync with each other, they can talk to each other,” he said.Source: https://www.ucdavis.edu/news/brain-wave-device-enhances-memory-function
In our study, we identified that certain recurrent mutations found in DNA stem loops, a common DNA structure, were in fact passenger hotspots and not the drivers we had originally believed them to be. More importantly, we discovered other recurrent mutations, found in DNA locations outside of stem loops, may be new drivers that are not yet characterized. The importance of our finding is that it gives us the ability to discriminate among mutations, which is essential in order to develop novel cancer therapies.”Rémi Buisson, PhD, an assistant professor in the Department of Biological Chemistry at the UCI School of Medicine and lead researcher on the study Related StoriesStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryNew study to ease plight of patients with advanced cancerNew protein target for deadly ovarian cancerResearch teams from UCI School of Medicine and Massachusetts General Hospital examined the mutation landscape and the distribution of mutations in the cancer genomes of more than 9,000 patient tumors. They identified that certain hotspot mutations arise from the activity of a family of proteins called APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like).”Our analyses show that APOBEC3A, in particular, has a strong preference for DNA structures called stem-loops or DNA hairpins. This preference results in the creation of hotspot mutations in patient tumors,” said Buisson.Tens of thousands of DNA damage events occur daily in human cells. The APOBEC family of proteins are one of the most common sources of endogenous DNA damage events in cancer cells. APOBEC3A directly attacks genomic DNA, inducing DNA double-strand breaks and mutations. Until now, little was known about how APOBEC3A targets genomic DNA and if some structures of the genome are more prone to APOBEC3A attacks than others. DNA stem-loop structures can be transiently generated during DNA replication, transcription or through diverse DNA repair processes. These multiple pathways provide many opportunities for APOBEC3A to promote structure-specific cytosine deamination favoring the emergence of passenger hotspot mutations in patient tumors. Source:University of California, Irvine Reviewed by Kate Anderton, B.Sc. (Editor)Jun 29 2019Until now, researchers believed recurrent mutations (hotspot mutations) in cancer tumors were the important mutations (driver mutations) that promoted cancer progression. A new University of California, Irvine-led study indicates this is not always true.Methods for identifying driver genes important to cancer progression have relied on the gold standard of recurrence across patients. Seeing exactly the same DNA base pair mutated repeatedly across many patients has been taken as incontrovertible proof that the mutation must be contributing to tumor development. However, the study, “Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features,” published today in Science, reveals many recurrent cancer mutations are likely passenger hotspot mutations and not important for cancer development.
At a 0.065 euros ($0.081) per kilowatt per hour before tax, the cost of electricity is nearly half the EU average.This makes Iceland one of the most competitive nations in Europe after Serbia, Macedonia and Bosnia. I lava you Iceland! – Bitcoin miner Genesis Mining has set up shop in the middle of a lava field But Iceland also has an advantage in its average annual temperature is about five degrees Celsius (41 Fahrenheit), meaning mining farms can for most of the time just suck in cool air from the outside instead of running energy-hungry air conditioners.The power usage efficiency “is really good in Iceland because of the natural cooling,” said Johann Snorri Sigurbergsson, director of business development at Iceland’s power company HS Orka. Shocking rise in demandA growing number of firms like Genesis Mining, which was previously based in Bosnia, have chosen to set up shop in Iceland, which means demand for electricity has shot up.”The demand has been increasing exponentially, especially the last three months,” said Sigurbergsson. The increase has come as the price of bitcoin has plunged from its peak of nearly $20,000 to below $9,000 currently, with analysts saying that the price decline has made operating costs even more of a concern for miners.Salter, who fears the growing competition in the sector, said bitcoin’s “price isn’t a very good indicator on how bitcoin mining industry is doing”. A rich seam in the bitcoin gold rush Bitcoin heist: 600 powerful computers stolen in Iceland Philip Salter, head of operations at Genesis Mining, inside the company’s bitcoin “farm” He may not have that much more competition from neighbours as Sigurbergsson said HS Orka “will not be able to supply all the demand” from miners wanting to set up operations.He said his firm is “in the great position of we can pick and choose who we can do business with”. HS Orka estimates that Iceland’s three largest bitcoin farming companies in 2018 will consume more electricity than the nation’s 350,000 inhabitants. Miners also have another worry: Even a virtual gold rush attracts real thieves.Between December 2017 and January 2018, equipment worth an estimated 1.6 million euros was stolen. Last year saw a meteoric rise of hundreds of virtual currencies led by bitcoin, which was fetching almost $20,000 per unit in December as both amateur and professional miners jumped onto the bandwagon.Home miners often use an old computer, have no choice where they operate, and are lucky if they get a fraction of a bitcoin every now and then.Professionals like Genesis Mining need to invest serious amounts to build and equip a facility like this one with a surface area a third of an Olympic-size pool, but which has a much greater chance of catching part of the 12.5 bitcoins created every ten minutes.They can choose where to set up operations, however, and that choice can have a huge impact on their profits as the price of the electricity to power and cool the computers varies considerably from country to country.Iceland is attractive for cryptocurrency mining because of its cheap electricity, which has the added advantage of being generated from clean geothermal energy. At a secret location in the midst of one of Iceland’s breathtaking lava fields stands a warehouse whose non-descript siding belies the fact it is ground zero in a digital gold rush for cryptocurrencies that is burning through more electricity than Icelanders’ homes. Citation: Volcanic growth for bitcoin in chilly Iceland (2018, March 28) retrieved 18 July 2019 from https://phys.org/news/2018-03-volcanic-growth-bitcoin-chilly-iceland.html © 2018 AFP Souped-up computers called mining rigs operate 24/7, using huge amounts of electricity and generating lots of heat Iceland’s combination of fire and ice not only makes it a stunning site to film parts of the medieval fantasy epic Game of Thrones. It also offers a unique combination of cheap renewable energy and free air conditioning that is making it a promised land for those “mining” virtual currencies, including bitcoin, using powerful computers that are voracious users of electricity and throw off lots of heat.And noise.The din from shelves and shelves of computers whirring inside the 400-square-metre (4,300-square-foot) warehouse rivals a jet during takeoff. Unlike the dollar and the euro, bitcoin is not issued by central banks. Instead it is “mined” or created in computer “farms” like this one. It uses computers souped up with six graphics cards tasked with the heavy lifting of thousands of thousands of calculations needed to solve complex algorithms to process bitcoin transactions and be rewarded with bitcoins in exchange.Cheap and cool Iceland”It’s possible for everyone to do it at home. There is no one stopping you (and) there are no technical limitations,” said Philip Salter, head of operations at Genesis Mining, told AFP. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Citation: WhatsApp CEO Jan Koum to leave Facebook amid privacy flap (2018, May 1) retrieved 18 July 2019 from https://phys.org/news/2018-05-whatsapp-ceo-jan-koum-facebook.html Koum confirmed his departure from WhatsApp Monday on his Facebook page . The Washington Post reported that Koum also plans to resign from Facebook’s board of directors. Facebook wouldn’t comment on that report.Facebook has been trying to defuse questions about whether it can be trusted with the reams of personal information it collects to sell ads and whether its social network does more harm than good.Koum didn’t elaborate on his reasons for leaving, other to say it was time to “move on” so he could spend more time “collecting rare air-cooled Porsches, working on my cars and playing ultimate frisbee.”But Koum also may have been embroiled in a rift with Facebook management over the parent company’s voracious appetite for personal information and WhatsApp’s dedication to user privacy, according to the Post report. WhatsApp uses encryption technology that makes messages indecipherable to everyone but the sender and recipient.WhatsApp also runs no ads. Facebook’s enormous profits, meanwhile, are powered almost entirely by advertising targeted to its users’ interests.Koum’s defection could put CEO Mark Zuckerberg in an uncomfortable position Tuesday, when he takes the stage at a company conference. In attendance will be more than 5,000 app software developers, some of whom may be WhatsApp users.Zuckerberg is already expected to reiterate some of the apologies he’s been offering in the wake of revelations that Facebook allowed Cambridge Analytica, a data mining firm tied to President Donald Trump’s 2016 campaign, to obtain personal information from as many as 87 million of its users.In a reply to Koum’s Facebook post, Zuckerberg told him he would miss working together.”I’m grateful for everything you’ve done to help connect the world, and for everything you’ve taught me, including about encryption and its ability to take power from centralized systems and put it back in people’s hands,” Zuckerberg wrote.Facebook bought WhatsApp for $19 billion in 2014, though without ever devising a clear strategy for how that service would make money. Both Koum, and WhatApp’s other co-founder, Brian Acton, had expressed an aversion to allowing ads into their service, causing analysts to wonder if the acquisition would ever pay off for Facebook.Acton left WhatsApp late last year and joined in the growing backlash against Facebook, endorsing a campaign that encouraged users to delete their profiles from the social network.But few of Facebook’s 2.2 billion users have departed so far, based on the audience and revenue growth the company reported last week.Koum also signaled years ago that he would take a stand against Facebook if the company’s push to increase its profits demanded radical changes in the way WhatsApp operates. In a blog post written when Facebook announced the biggest acquisition in its history, Koum wrote that the deal wouldn’t have happened if WhatsApp “had to compromise on the core principles that will always define our company, our vision and our product.” In this Monday, Feb. 24, 2014, file photo, Whatsapp co-founder and CEO Jan Koum speaks during a conference at the Mobile World Congress, the world’s largest mobile phone trade show in Barcelona, Spain. On Monday, April 30, 2018, Koum confirmed on his Facebook page that he is leaving Whatsapp and Facebook, saying it is time for him to “move on.” (AP Photo/Manu Fernandez, File) Explore further WhatsApp CEO Jan Koum is breaking ties with his company’s parent, Facebook, amid a privacy scandal that has dogged the social network for weeks. © 2018 The Associated Press. All rights reserved. WhatsApp to add voice to messaging service This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
On July 20, 1969, an estimated 650 million people watched in suspense as Neil Armstrong descended a ladder towards the surface of the Moon. As he took his first steps, he uttered words that would be written into history books for generations to come: “That’s one small step for man. One giant leap for mankind.” Or at least that’s how the media reported his words.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65950-neil-armstrong-first-words-on-moon.html?jwsource=cl已复制直播00:0000:3500:35 But Armstrong insisted that he actually said, “That’s one small step for a man.” In fact, in the official transcript of the Moon landing mission, NASA transcribes the quote as “that’s one small step for (a) man.” As a linguist, I’m fascinated by mistakes between what people say and what people hear. In fact, I recently conducted a study on ambiguous speech, using Armstrong’s famous quote to try to figure out why and how we successfully understand speech most of the time, but also make the occasional mistake. Our extraordinary speech-processing abilities Despite confusion over Armstrong’s words, speakers and listeners have a remarkable ability to agree on what is said and what is heard. When we talk, we formulate a thought, retrieve words from memory and move our mouths to produce sound. We do this quickly, producing, in English, around five syllables every second. The process for listeners is equally complex and speedy. We hear sounds, which we separate into speech and non-speech information, combine the speech sounds into words, and determine the meanings of these words. Again, this happens nearly instantaneously, and errors rarely occur. These processes are even more extraordinary when you think more closely about the properties of speech. Unlike writing, speech doesn’t have spaces between words. When people speak, there are typically very few pauses within a sentence. Yet listeners have little trouble determining word boundaries in real time. This is because there are little cues — like pitch and rhythm — that indicate when one word stops and the next begins. But problems in speech perception can arise when those kinds of cues are missing, especially when pitch and rhythm are used for non-linguistic purposes, like in music. This is one reason why misheard song lyrics — called “mondegreens” — are common. When singing or rapping, a lot of the speech cues we usually use are shifted to accommodate the song’s beat, which can end up jamming our default perception process. But it’s not just lyrics that are misheard. This can happen in everyday speech, and some have wondered if this is what happened in the case of Neil Armstrong. Studying Armstrong’s mixed signals Over the years, researchers have tried to comb the audio files of Armstrong’s famous words, with mixed results. Some have suggested that Armstrong definitely produced the infamous “a,” while others maintain that it’s unlikely or too difficult to tell. But the original sound file was recorded 50 years ago, and the quality is pretty poor. So can we ever really know whether Neil Armstrong uttered that little “a”? Perhaps not. But in a recent study, my colleagues and I tried to get to the bottom of this. First, we explored how similar the speech signals are when a speaker intends to say “for” or “for a.” That is, could a production of “for” be consistent with the sound waves, or acoustics, of “for a,” and vice-versa? So we examined nearly 200 productions of “for” and 200 productions of “for a.” We found that the acoustics of the productions of each of these tokens were nearly identical. In other words, the sound waves produced by “He bought it for a school” and “He bought one for school” are strikingly similar. But this doesn’t tell us what Armstrong actually said on that July day in 1969. So we wanted to see if listeners sometimes miss little words like “a” in contexts like Armstrong’s phrase. We wondered whether “a” was always perceived by listeners, even when it was clearly produced. And we found that, in several studies, listeners often misheard short words, like “a.” This is especially true when the speaking rate was as slow as Armstrong’s. In addition, we were able to manipulate whether or not people heard these short words just by altering the rate of speech. So perhaps this was a perfect storm of conditions for listeners to misperceive the intended meaning of this famous quote. The case of the missing “a” is one example of the challenges in producing and understanding speech. Nonetheless, we typically perceive and produce speech quickly, easily and without conscious effort. A better understanding of this process can be especially useful when trying to help people with speech or hearing impairments. And it allows researchers to better understand how these skills are learned by adults trying to acquire a new language, which can, in turn, help language learners develop more efficient strategies. Fifty years ago, humanity was changed when Neil Armstrong took those first steps on the Moon. But he probably didn’t realize that his famous first words could also help us better understand how humans communicate. [Sign up for The Conversation’s newsletter to get insight each day] Melissa Michaud Baese-Berk, Associate Professor of Linguistics, University of Oregon This article is republished from The Conversation under a Creative Commons license. 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Next 5 employees suspended for remaining absent from duty in J-K’s RajouriA team of officers of the district administration inspected 11 offices of various government departments located at the district headquarter and found five employees absent without leave.advertisement Press Trust of India JammuJuly 12, 2019UPDATED: July 12, 2019 22:57 IST Government offices inspected including Geology and Mining office | REUTERS image for representationHIGHLIGHTSA team of officers of district administration inspected 11 offices of various government departmentsFive employees from different departments were suspended in RajouriThey were suspended for remaining absent from dutyFive government employees of different departments were suspended for remaining absent from duty on Friday in Jammu and Kashmir’s Rajouri district, officials said.A team of officers of the district administration inspected 11 offices of various government departments located at the district headquarter and found five employees absent without leave, they said.The government offices inspected are the Animal Husbandry Department, Sales Tax office, Geology and Mining office, Excise and Taxation office, IWMP office, Child Development Project Office, General Provident office, District Forest office (Social Forestry), Cooperatives office, Fisheries Office and the Pollution Control Board office.The employees were placed under suspension, they said.Also Read | Amit Shah’s mission Kashmir banks on newly elected panch, sarpanch for developmentAlso Read | Preparing to hold Jammu & Kashmir elections by end of 2019, says Amit ShahAlso Watch | India Today investigation: Know what is happening in Jammu & KashmirFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byMohak Gupta Tags :Follow Jammu and KashmirFollow Rajouri